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The three settlements, covering 60 acres, became a commercial hub and in 1768 became the county seat.Baltimore played a key part in events leading to and including the American Revolution. moved the city to join the resistance to British taxes, and merchants signed agreements to not trade with Britain.As of 2016, the population of the Baltimore metropolitan area was estimated to be just under 2.8 million, making it the 21st largest metropolitan area in the country.Baltimore is located about 40 miles northeast of Washington, D.Soon after the city created the world's first dental college, the Baltimore College of Dental Surgery, in 1840, and shared in the world's first telegraph line, between Baltimore and Washington DC in 1844.Maryland, a slave state with abundant popular support for secession in some areas, remained part of the Union during the American Civil War, due in part to the Union's strategic occupation of the city in 1861.and is home to some of the earliest National Register Historic Districts in the nation, including Fell's Point, Federal Hill, and Mount Vernon, which were added to the National Register between 1969–1971. The city has 66 National Register Historic Districts and 33 local historic districts. The Baltimore area had been inhabited by Native Americans since at least the 10th millennium BC, when Paleo-Indians first settled in the region.
After a decline in major manufacturing, industrialization, and rail transportation, Baltimore shifted to a service-oriented economy, with Johns Hopkins Hospital (founded 1889) and Johns Hopkins University (founded 1876), now the city's top two employers.
The Baltimore riot cost the city an estimated million (US$ 69 million in 2017).
A total of 11,000 Maryland National Guard and federal troops were ordered into the city.
European colonization of Maryland began with the arrival of an English ship at St. Europeans began to settle the area further north, beginning to populate the area of Baltimore County, The colonial General Assembly of Maryland created the Port of Baltimore at old Whetstone Point (now Locust Point) in 1706 for the tobacco trade.
The Town of Baltimore, on the west side of the Jones Falls, was founded and laid out on July 30, 1729; with Jonestown and Fells Point preexisting to the east.By 1820 its population had reached 60,000, and its economy had shifted from its base in tobacco plantations to sawmilling, shipbuilding, and textile production.